Study Finds Some Elite Controllers Indistinguishable From HIV-negative Persons Print E-mail
  
Wednesday, 22 December 2010 12:46
In an abstract published online ahead of print today in the Journal of Virology, International HIV Controller Study collaborators characterized genetic signatures in the CD4 T-cells of an "unselected" cohort of elite controllers to further elucidate underlying immunological and virological mechanisms of HIV-1 control. Genetic profiles of the majority of elite controllers were similiar to patients on antiretroviral therapy, although different from HIV-1 negative persons. However, in a smaller proportion of elite controllers, an alternative genetic pattern was observed that was indistinguishable from that of HIV-1 negative persons, and different from individuals on highly active antiretroviral medications. Significantly higher CD4 T-cell counts and smaller levels of HIV-1 specific CD8+ T-cell responses were measured in this sub-group of elite controllers. who did not significantly differ from other elite controllers in respect to viral loads and HLA class I alleles. This study team concludes that the data identify a "specific subgroup of elite controllers whose immunological and gene expression characteristics approximate those of HIV-1 negative persons."
Abstract Accessed 12/22/10, at: http://jvi.asm.org/cgi/content/abstract/JVI.01846-10v1
Del.icio.us     Digg This!     Facebook     Google     Reddit     Stumble It!
Last Updated ( Wednesday, 12 January 2011 22:36 )
 

Please Donate!

Please make a tax deductible donation to Zephyr LTNP Foundation, a 501(c)(3) entity via Paypal. No Paypal account required.
 

CROI 2011

  • Wednesday 9th March 2011
    This is our final bulletin from CROI 2011. We hope you have found our news coverage useful. You can find all our coverage at www.aidsmap.com/croi2011, including the news reports and bulletins.We are always looking for ways of improving and developing our resources – so if you have any comments that you would like
  • Thursday 3rd March 2011
    There is increasing evidence of the transmission of HIV strains with resistance to anti-HIV drugs in low- and middle-income countries. Research in eleven sub-Saharan African countries showed that the chances of detecting transmitted resistance increased by over a third each year that a country had been scaling up HIV treatment. A separate study involving people recently diagnosed
  • Wednesday 2nd March 2011
    A new type of anti-HIV drug that targets the first step in HIV’s entry into cells has done well in a Phase IIa study. Currently known as BMS-663068, the drug was shown to be safe and to work against the virus. HIV cell entry is a three-step process. The virus must first attach to the

Follow Us

  • Facebook Page: zephyrfoundation.org
  • Twitter: zephyrfound
  • YouTube: zephyrfoundation

Controllers in Study

 Donation Thermometer
 Donation Thermometer
 Donation Thermometer
86%

Our Goal:
2000
Currently:
1725
Updated:
December 30, 2009

Current Breakdown: 505 Elite Controllers 1009 Viremic Controllers 211 Other