Strict Standards: Non-static method JLoader::import() should not be called statically in /home/zephyr/public_html/libraries/joomla/import.php on line 29

Strict Standards: Non-static method JLoader::register() should not be called statically in /home/zephyr/public_html/libraries/loader.php on line 71

Strict Standards: Non-static method JLoader::import() should not be called statically in /home/zephyr/public_html/libraries/joomla/import.php on line 32

Strict Standards: Non-static method JLoader::register() should not be called statically in /home/zephyr/public_html/libraries/loader.php on line 71

Strict Standards: Non-static method JLoader::load() should not be called statically in /home/zephyr/public_html/libraries/loader.php on line 161

Strict Standards: Non-static method JLoader::register() should not be called statically in /home/zephyr/public_html/libraries/loader.php on line 138

Strict Standards: Non-static method JRequest::clean() should not be called statically in /home/zephyr/public_html/libraries/joomla/import.php on line 33

Strict Standards: Non-static method JRequest::_cleanArray() should not be called statically in /home/zephyr/public_html/libraries/joomla/environment/request.php on line 463

Strict Standards: Non-static method JRequest::_cleanArray() should not be called statically in /home/zephyr/public_html/libraries/joomla/environment/request.php on line 464

Strict Standards: Non-static method JRequest::_cleanArray() should not be called statically in /home/zephyr/public_html/libraries/joomla/environment/request.php on line 465

Strict Standards: Non-static method JRequest::_cleanArray() should not be called statically in /home/zephyr/public_html/libraries/joomla/environment/request.php on line 466

Strict Standards: Non-static method JRequest::_cleanArray() should not be called statically in /home/zephyr/public_html/libraries/joomla/environment/request.php on line 467

Strict Standards: Non-static method JRequest::_cleanArray() should not be called statically in /home/zephyr/public_html/libraries/joomla/environment/request.php on line 468

Strict Standards: Non-static method JLoader::import() should not be called statically in /home/zephyr/public_html/libraries/joomla/import.php on line 35

Strict Standards: Non-static method JLoader::register() should not be called statically in /home/zephyr/public_html/libraries/loader.php on line 71

Strict Standards: Non-static method JLoader::import() should not be called statically in /home/zephyr/public_html/libraries/joomla/import.php on line 38

Strict Standards: Non-static method JLoader::register() should not be called statically in /home/zephyr/public_html/libraries/loader.php on line 71

Strict Standards: Non-static method JLoader::import() should not be called statically in /home/zephyr/public_html/libraries/joomla/import.php on line 39

Strict Standards: Non-static method JLoader::register() should not be called statically in /home/zephyr/public_html/libraries/loader.php on line 71

Strict Standards: Non-static method JLoader::load() should not be called statically in /home/zephyr/public_html/libraries/loader.php on line 161

Strict Standards: Non-static method JLoader::register() should not be called statically in /home/zephyr/public_html/libraries/loader.php on line 138

Strict Standards: Non-static method JLoader::import() should not be called statically in /home/zephyr/public_html/libraries/joomla/import.php on line 46

Strict Standards: Non-static method JLoader::register() should not be called statically in /home/zephyr/public_html/libraries/loader.php on line 71

Strict Standards: Non-static method JLoader::import() should not be called statically in /home/zephyr/public_html/libraries/joomla/import.php on line 47

Strict Standards: Non-static method JLoader::register() should not be called statically in /home/zephyr/public_html/libraries/loader.php on line 71

Strict Standards: Non-static method JLoader::import() should not be called statically in /home/zephyr/public_html/libraries/joomla/import.php on line 50

Strict Standards: Non-static method JLoader::register() should not be called statically in /home/zephyr/public_html/libraries/loader.php on line 71

Strict Standards: Non-static method JLoader::import() should not be called statically in /home/zephyr/public_html/libraries/joomla/import.php on line 53

Strict Standards: Non-static method JLoader::register() should not be called statically in /home/zephyr/public_html/libraries/loader.php on line 71

Strict Standards: Non-static method JLoader::import() should not be called statically in /home/zephyr/public_html/libraries/joomla/import.php on line 54

Strict Standards: Non-static method JLoader::register() should not be called statically in /home/zephyr/public_html/libraries/loader.php on line 71

Strict Standards: Non-static method JLoader::register() should not be called statically in /home/zephyr/public_html/libraries/joomla/import.php on line 57

Strict Standards: Non-static method JLoader::register() should not be called statically in /home/zephyr/public_html/libraries/joomla/import.php on line 58

Strict Standards: Non-static method JLoader::import() should not be called statically in /home/zephyr/public_html/libraries/loader.php on line 186

Strict Standards: Non-static method JLoader::register() should not be called statically in /home/zephyr/public_html/libraries/loader.php on line 71

Strict Standards: Non-static method JLoader::import() should not be called statically in /home/zephyr/public_html/libraries/loader.php on line 186

Strict Standards: Non-static method JLoader::register() should not be called statically in /home/zephyr/public_html/libraries/loader.php on line 71

Strict Standards: Non-static method JLoader::import() should not be called statically in /home/zephyr/public_html/libraries/loader.php on line 186

Strict Standards: Non-static method JLoader::register() should not be called statically in /home/zephyr/public_html/libraries/loader.php on line 71

Strict Standards: Non-static method JLoader::import() should not be called statically in /home/zephyr/public_html/libraries/loader.php on line 186

Strict Standards: Non-static method JLoader::register() should not be called statically in /home/zephyr/public_html/libraries/loader.php on line 71

Strict Standards: Non-static method JLoader::import() should not be called statically in /home/zephyr/public_html/libraries/loader.php on line 186

Strict Standards: Non-static method JLoader::register() should not be called statically in /home/zephyr/public_html/libraries/loader.php on line 71

Strict Standards: Non-static method JLoader::import() should not be called statically in /home/zephyr/public_html/libraries/loader.php on line 186

Strict Standards: Non-static method JLoader::register() should not be called statically in /home/zephyr/public_html/libraries/loader.php on line 71

Strict Standards: Non-static method JLoader::import() should not be called statically in /home/zephyr/public_html/libraries/loader.php on line 186

Strict Standards: Non-static method JLoader::register() should not be called statically in /home/zephyr/public_html/libraries/loader.php on line 71

Strict Standards: Non-static method JLoader::import() should not be called statically in /home/zephyr/public_html/libraries/loader.php on line 186

Strict Standards: Non-static method JLoader::register() should not be called statically in /home/zephyr/public_html/libraries/loader.php on line 71

Strict Standards: Non-static method JLoader::import() should not be called statically in /home/zephyr/public_html/libraries/loader.php on line 186

Strict Standards: Non-static method JLoader::register() should not be called statically in /home/zephyr/public_html/libraries/loader.php on line 71

Strict Standards: Non-static method JLoader::load() should not be called statically in /home/zephyr/public_html/libraries/loader.php on line 161

Strict Standards: Non-static method JLoader::register() should not be called statically in /home/zephyr/public_html/libraries/loader.php on line 138

Strict Standards: Non-static method JFactory::getApplication() should not be called statically in /home/zephyr/public_html/index.php on line 31

Strict Standards: Non-static method JLoader::import() should not be called statically in /home/zephyr/public_html/libraries/loader.php on line 186

Strict Standards: Non-static method JLoader::register() should not be called statically in /home/zephyr/public_html/libraries/loader.php on line 71

Strict Standards: Non-static method JLoader::load() should not be called statically in /home/zephyr/public_html/libraries/loader.php on line 161

Strict Standards: Non-static method JLoader::register() should not be called statically in /home/zephyr/public_html/libraries/loader.php on line 138

Strict Standards: Non-static method JLoader::import() should not be called statically in /home/zephyr/public_html/libraries/loader.php on line 186

Strict Standards: Non-static method JLoader::load() should not be called statically in /home/zephyr/public_html/libraries/loader.php on line 161

Strict Standards: Non-static method JLoader::register() should not be called statically in /home/zephyr/public_html/libraries/loader.php on line 138

Strict Standards: Redefining already defined constructor for class JObject in /home/zephyr/public_html/libraries/joomla/base/object.php on line 57

Strict Standards: Non-static method JApplication::getInstance() should not be called statically in /home/zephyr/public_html/libraries/joomla/factory.php on line 46

Strict Standards: Non-static method JLoader::import() should not be called statically in /home/zephyr/public_html/libraries/loader.php on line 186

Strict Standards: Non-static method JLoader::register() should not be called statically in /home/zephyr/public_html/libraries/loader.php on line 71

Strict Standards: Non-static method JLoader::load() should not be called statically in /home/zephyr/public_html/libraries/loader.php on line 161

Strict Standards: Non-static method JLoader::register() should not be called statically in /home/zephyr/public_html/libraries/loader.php on line 138

Strict Standards: Non-static method JApplicationHelper::getClientInfo() should not be called statically in /home/zephyr/public_html/libraries/joomla/application/application.php on line 132

Strict Standards: Declaration of JSite::getRouter() should be compatible with & JApplication::getRouter($name = NULL, $options = Array) in /home/zephyr/public_html/includes/application.php on line 377

Strict Standards: Declaration of JSite::getPathWay() should be compatible with & JApplication::getPathway($name = NULL, $options = Array) in /home/zephyr/public_html/includes/application.php on line 377

Strict Standards: Declaration of JSite::getMenu() should be compatible with & JApplication::getMenu($name = NULL, $options = Array) in /home/zephyr/public_html/includes/application.php on line 377

Strict Standards: Non-static method JLoader::import() should not be called statically in /home/zephyr/public_html/libraries/loader.php on line 186

Strict Standards: Non-static method JLoader::register() should not be called statically in /home/zephyr/public_html/libraries/loader.php on line 71

Strict Standards: Non-static method JLoader::import() should not be called statically in /home/zephyr/public_html/libraries/loader.php on line 186

Strict Standards: Non-static method JLoader::import() should not be called statically in /home/zephyr/public_html/libraries/loader.php on line 186

Strict Standards: Non-static method JLoader::register() should not be called statically in /home/zephyr/public_html/libraries/loader.php on line 71

Strict Standards: Non-static method JLoader::import() should not be called statically in /home/zephyr/public_html/libraries/loader.php on line 186

Strict Standards: Non-static method JLoader::load() should not be called statically in /home/zephyr/public_html/libraries/loader.php on line 161

Strict Standards: Non-static method JLoader::register() should not be called statically in /home/zephyr/public_html/libraries/loader.php on line 138

Strict Standards: Non-static method JLoader::register() should not be called statically in /home/zephyr/public_html/libraries/joomla/registry/registry.php on line 19

Strict Standards: Non-static method JLoader::load() should not be called statically in /home/zephyr/public_html/libraries/loader.php on line 161

Strict Standards: Non-static method JLoader::register() should not be called statically in /home/zephyr/public_html/libraries/loader.php on line 138

Strict Standards: Non-static method JLoader::import() should not be called statically in /home/zephyr/public_html/libraries/loader.php on line 186

Strict Standards: Non-static method JLoader::register() should not be called statically in /home/zephyr/public_html/libraries/loader.php on line 71

Strict Standards: Non-static method JLoader::load() should not be called statically in /home/zephyr/public_html/libraries/loader.php on line 161

Strict Standards: Non-static method JLoader::register() should not be called statically in /home/zephyr/public_html/libraries/loader.php on line 138

Strict Standards: Declaration of JSession::set() should be compatible with JObject::set($property, $value = NULL) in /home/zephyr/public_html/libraries/joomla/session/session.php on line 725

Strict Standards: Non-static method JLoader::register() should not be called statically in /home/zephyr/public_html/libraries/joomla/session/session.php on line 19

Strict Standards: Non-static method JLoader::load() should not be called statically in /home/zephyr/public_html/libraries/loader.php on line 161

Strict Standards: Non-static method JLoader::register() should not be called statically in /home/zephyr/public_html/libraries/loader.php on line 138

Strict Standards: Non-static method JLoader::load() should not be called statically in /home/zephyr/public_html/libraries/loader.php on line 161

Strict Standards: Non-static method JLoader::register() should not be called statically in /home/zephyr/public_html/libraries/loader.php on line 138

Strict Standards: Non-static method JLoader::load() should not be called statically in /home/zephyr/public_html/libraries/loader.php on line 161

Strict Standards: Non-static method JLoader::register() should not be called statically in /home/zephyr/public_html/libraries/loader.php on line 138

Strict Standards: Non-static method JLoader::import() should not be called statically in /home/zephyr/public_html/libraries/loader.php on line 186

Strict Standards: Non-static method JLoader::register() should not be called statically in /home/zephyr/public_html/libraries/loader.php on line 71

Strict Standards: Non-static method JLoader::import() should not be called statically in /home/zephyr/public_html/libraries/loader.php on line 186

Strict Standards: Non-static method JLoader::register() should not be called statically in /home/zephyr/public_html/libraries/loader.php on line 71

Strict Standards: Non-static method JLoader::load() should not be called statically in /home/zephyr/public_html/libraries/loader.php on line 161

Strict Standards: Non-static method JLoader::register() should not be called statically in /home/zephyr/public_html/libraries/loader.php on line 138

Strict Standards: Non-static method JLoader::load() should not be called statically in /home/zephyr/public_html/libraries/loader.php on line 161

Strict Standards: Non-static method JLoader::register() should not be called statically in /home/zephyr/public_html/libraries/loader.php on line 138

Strict Standards: Non-static method JLoader::load() should not be called statically in /home/zephyr/public_html/libraries/loader.php on line 161

Strict Standards: Non-static method JLoader::register() should not be called statically in /home/zephyr/public_html/libraries/loader.php on line 138

Strict Standards: Non-static method JLoader::load() should not be called statically in /home/zephyr/public_html/libraries/loader.php on line 161

Strict Standards: Non-static method JLoader::register() should not be called statically in /home/zephyr/public_html/libraries/loader.php on line 138

Strict Standards: Non-static method JLoader::import() should not be called statically in /home/zephyr/public_html/libraries/loader.php on line 186

Strict Standards: Non-static method JLoader::register() should not be called statically in /home/zephyr/public_html/libraries/loader.php on line 71

Strict Standards: Non-static method JLoader::load() should not be called statically in /home/zephyr/public_html/libraries/loader.php on line 161

Strict Standards: Non-static method JLoader::register() should not be called statically in /home/zephyr/public_html/libraries/loader.php on line 138

Strict Standards: Non-static method JLoader::import() should not be called statically in /home/zephyr/public_html/libraries/loader.php on line 186

Strict Standards: Non-static method JLoader::load() should not be called statically in /home/zephyr/public_html/libraries/loader.php on line 161

Strict Standards: Non-static method JLoader::register() should not be called statically in /home/zephyr/public_html/libraries/loader.php on line 138

Strict Standards: Non-static method JLoader::import() should not be called statically in /home/zephyr/public_html/libraries/loader.php on line 186

Strict Standards: Non-static method JLoader::register() should not be called statically in /home/zephyr/public_html/libraries/loader.php on line 71

Strict Standards: Non-static method JLoader::load() should not be called statically in /home/zephyr/public_html/libraries/loader.php on line 161

Strict Standards: Non-static method JLoader::register() should not be called statically in /home/zephyr/public_html/libraries/loader.php on line 138

Strict Standards: Non-static method JLoader::import() should not be called statically in /home/zephyr/public_html/libraries/loader.php on line 186

Strict Standards: Non-static method JLoader::register() should not be called statically in /home/zephyr/public_html/libraries/joomla/html/parameter.php on line 21

Strict Standards: Non-static method JLoader::import() should not be called statically in /home/zephyr/public_html/libraries/loader.php on line 186

Strict Standards: Non-static method JLoader::load() should not be called statically in /home/zephyr/public_html/libraries/loader.php on line 161

Strict Standards: Non-static method JLoader::register() should not be called statically in /home/zephyr/public_html/libraries/loader.php on line 138

Strict Standards: Non-static method JLoader::load() should not be called statically in /home/zephyr/public_html/libraries/loader.php on line 161

Strict Standards: Non-static method JLoader::register() should not be called statically in /home/zephyr/public_html/libraries/loader.php on line 138

Strict Standards: Non-static method JLoader::load() should not be called statically in /home/zephyr/public_html/libraries/loader.php on line 161

Strict Standards: Non-static method JLoader::register() should not be called statically in /home/zephyr/public_html/libraries/loader.php on line 138

Strict Standards: Declaration of JRegistryFormatINI::objectToString() should be compatible with JRegistryFormat::objectToString(&$object) in /home/zephyr/public_html/libraries/joomla/registry/format/ini.php on line 281

Strict Standards: Non-static method JLoader::load() should not be called statically in /home/zephyr/public_html/libraries/loader.php on line 161

Strict Standards: Non-static method JLoader::register() should not be called statically in /home/zephyr/public_html/libraries/loader.php on line 138

Strict Standards: Non-static method JLoader::import() should not be called statically in /home/zephyr/public_html/libraries/loader.php on line 186

Strict Standards: Non-static method JLoader::register() should not be called statically in /home/zephyr/public_html/libraries/loader.php on line 71

Strict Standards: Non-static method JLoader::load() should not be called statically in /home/zephyr/public_html/libraries/loader.php on line 161

Strict Standards: Non-static method JLoader::register() should not be called statically in /home/zephyr/public_html/libraries/loader.php on line 138

Strict Standards: Non-static method JLoader::import() should not be called statically in /home/zephyr/public_html/libraries/loader.php on line 186

Strict Standards: Non-static method JLoader::import() should not be called statically in /home/zephyr/public_html/libraries/loader.php on line 186

Strict Standards: Non-static method JLoader::register() should not be called statically in /home/zephyr/public_html/libraries/loader.php on line 71

Strict Standards: Non-static method JLoader::import() should not be called statically in /home/zephyr/public_html/libraries/loader.php on line 186

Strict Standards: Non-static method JLoader::load() should not be called statically in /home/zephyr/public_html/libraries/loader.php on line 161

Strict Standards: Non-static method JLoader::register() should not be called statically in /home/zephyr/public_html/libraries/loader.php on line 138

Strict Standards: Non-static method JLoader::import() should not be called statically in /home/zephyr/public_html/libraries/loader.php on line 186

Strict Standards: Non-static method JPluginHelper::importPlugin() should not be called statically in /home/zephyr/public_html/index.php on line 41

Strict Standards: Non-static method JPluginHelper::_load() should not be called statically in /home/zephyr/public_html/libraries/joomla/plugin/helper.php on line 92

Strict Standards: Non-static method JPluginHelper::_import() should not be called statically in /home/zephyr/public_html/libraries/joomla/plugin/helper.php on line 97

Strict Standards: Non-static method JLoader::import() should not be called statically in /home/zephyr/public_html/libraries/loader.php on line 186

Strict Standards: Non-static method JLoader::register() should not be called statically in /home/zephyr/public_html/libraries/loader.php on line 71

Strict Standards: Non-static method JLoader::import() should not be called statically in /home/zephyr/public_html/libraries/loader.php on line 186

Strict Standards: Non-static method JLoader::load() should not be called statically in /home/zephyr/public_html/libraries/loader.php on line 161

Strict Standards: Non-static method JLoader::register() should not be called statically in /home/zephyr/public_html/libraries/loader.php on line 138

Strict Standards: Redefining already defined constructor for class JPlugin in /home/zephyr/public_html/libraries/joomla/plugin/plugin.php on line 75

Strict Standards: Non-static method JLoader::import() should not be called statically in /home/zephyr/public_html/libraries/loader.php on line 186

Strict Standards: Non-static method JLoader::load() should not be called statically in /home/zephyr/public_html/libraries/loader.php on line 161

Strict Standards: Non-static method JLoader::register() should not be called statically in /home/zephyr/public_html/libraries/loader.php on line 138

Strict Standards: Non-static method JLoader::import() should not be called statically in /home/zephyr/public_html/libraries/loader.php on line 186

Strict Standards: Non-static method JLoader::register() should not be called statically in /home/zephyr/public_html/libraries/loader.php on line 71

Strict Standards: Non-static method JLoader::load() should not be called statically in /home/zephyr/public_html/libraries/loader.php on line 161

Strict Standards: Non-static method JLoader::register() should not be called statically in /home/zephyr/public_html/libraries/loader.php on line 138

Strict Standards: Declaration of JEvent::update() should be compatible with JObserver::update() in /home/zephyr/public_html/libraries/joomla/event/event.php on line 29

Strict Standards: Non-static method JLoader::load() should not be called statically in /home/zephyr/public_html/libraries/loader.php on line 161

Strict Standards: Non-static method JLoader::register() should not be called statically in /home/zephyr/public_html/libraries/loader.php on line 138

Strict Standards: Non-static method JLoader::import() should not be called statically in /home/zephyr/public_html/libraries/loader.php on line 186

Strict Standards: Non-static method JLoader::register() should not be called statically in /home/zephyr/public_html/libraries/loader.php on line 71

Strict Standards: Non-static method JLoader::load() should not be called statically in /home/zephyr/public_html/libraries/loader.php on line 161

Strict Standards: Non-static method JLoader::register() should not be called statically in /home/zephyr/public_html/libraries/loader.php on line 138

Strict Standards: Non-static method JDispatcher::getInstance() should not be called statically in /home/zephyr/public_html/libraries/joomla/plugin/helper.php on line 140

Strict Standards: Non-static method JPluginHelper::getPlugin() should not be called statically in /home/zephyr/public_html/libraries/joomla/plugin/helper.php on line 147

Strict Standards: Non-static method JPluginHelper::_load() should not be called statically in /home/zephyr/public_html/libraries/joomla/plugin/helper.php on line 41

Strict Standards: Non-static method JPluginHelper::_import() should not be called statically in /home/zephyr/public_html/libraries/joomla/plugin/helper.php on line 97

Strict Standards: Non-static method JLoader::import() should not be called statically in /home/zephyr/public_html/libraries/loader.php on line 186

Strict Standards: Non-static method JDispatcher::getInstance() should not be called statically in /home/zephyr/public_html/libraries/joomla/plugin/helper.php on line 140

Strict Standards: Non-static method JLoader::load() should not be called statically in /home/zephyr/public_html/libraries/loader.php on line 161

Strict Standards: Non-static method JLoader::register() should not be called statically in /home/zephyr/public_html/libraries/loader.php on line 138

Strict Standards: Non-static method JPluginHelper::_import() should not be called statically in /home/zephyr/public_html/libraries/joomla/plugin/helper.php on line 97

Strict Standards: Non-static method JLoader::import() should not be called statically in /home/zephyr/public_html/libraries/loader.php on line 186

Strict Standards: Non-static method JLoader::import() should not be called statically in /home/zephyr/public_html/libraries/loader.php on line 186

Strict Standards: Non-static method JDispatcher::getInstance() should not be called statically in /home/zephyr/public_html/libraries/joomla/plugin/helper.php on line 140

Strict Standards: Non-static method JPluginHelper::getPlugin() should not be called statically in /home/zephyr/public_html/libraries/joomla/plugin/helper.php on line 147

Strict Standards: Non-static method JPluginHelper::_load() should not be called statically in /home/zephyr/public_html/libraries/joomla/plugin/helper.php on line 41

Strict Standards: Non-static method JPluginHelper::_import() should not be called statically in /home/zephyr/public_html/libraries/joomla/plugin/helper.php on line 97

Strict Standards: Non-static method JLoader::import() should not be called statically in /home/zephyr/public_html/libraries/loader.php on line 186

Strict Standards: Non-static method JLoader::import() should not be called statically in /home/zephyr/public_html/libraries/loader.php on line 186

Strict Standards: Non-static method JDispatcher::getInstance() should not be called statically in /home/zephyr/public_html/libraries/joomla/plugin/helper.php on line 140

Strict Standards: Non-static method JPluginHelper::getPlugin() should not be called statically in /home/zephyr/public_html/libraries/joomla/plugin/helper.php on line 147

Strict Standards: Non-static method JPluginHelper::_load() should not be called statically in /home/zephyr/public_html/libraries/joomla/plugin/helper.php on line 41

Strict Standards: Non-static method JLoader::import() should not be called statically in /home/zephyr/public_html/libraries/loader.php on line 186

Strict Standards: Non-static method JLoader::import() should not be called statically in /home/zephyr/public_html/libraries/loader.php on line 186

Strict Standards: Non-static method JLoader::register() should not be called statically in /home/zephyr/public_html/libraries/loader.php on line 71

Strict Standards: Non-static method JLoader::load() should not be called statically in /home/zephyr/public_html/libraries/loader.php on line 161

Strict Standards: Non-static method JLoader::register() should not be called statically in /home/zephyr/public_html/libraries/loader.php on line 138

Strict Standards: Non-static method JPluginHelper::_import() should not be called statically in /home/zephyr/public_html/libraries/joomla/plugin/helper.php on line 97

Strict Standards: Non-static method JLoader::import() should not be called statically in /home/zephyr/public_html/libraries/loader.php on line 186

Strict Standards: Non-static method JLoader::import() should not be called statically in /home/zephyr/public_html/libraries/loader.php on line 186

Strict Standards: Non-static method JDispatcher::getInstance() should not be called statically in /home/zephyr/public_html/libraries/joomla/plugin/helper.php on line 140

Strict Standards: Non-static method JPluginHelper::getPlugin() should not be called statically in /home/zephyr/public_html/libraries/joomla/plugin/helper.php on line 147

Strict Standards: Non-static method JPluginHelper::_load() should not be called statically in /home/zephyr/public_html/libraries/joomla/plugin/helper.php on line 41

Strict Standards: Non-static method JLoader::load() should not be called statically in /home/zephyr/public_html/libraries/loader.php on line 161

Strict Standards: Non-static method JLoader::register() should not be called statically in /home/zephyr/public_html/libraries/loader.php on line 138

Strict Standards: Non-static method JLoader::load() should not be called statically in /home/zephyr/public_html/libraries/loader.php on line 161

Strict Standards: Non-static method JLoader::register() should not be called statically in /home/zephyr/public_html/libraries/loader.php on line 138

Strict Standards: Non-static method JLoader::load() should not be called statically in /home/zephyr/public_html/libraries/loader.php on line 161

Strict Standards: Non-static method JLoader::register() should not be called statically in /home/zephyr/public_html/libraries/loader.php on line 138

Strict Standards: Declaration of database::loadObject() should be compatible with JDatabaseMySQL::loadObject() in /home/zephyr/public_html/plugins/system/legacy/mysql.php on line 80

Strict Standards: Non-static method JLoader::register() should not be called statically in /home/zephyr/public_html/plugins/system/legacy/mysql.php on line 19

Strict Standards: Non-static method JLoader::import() should not be called statically in /home/zephyr/public_html/libraries/loader.php on line 186

Strict Standards: Non-static method JLoader::load() should not be called statically in /home/zephyr/public_html/libraries/loader.php on line 161

Strict Standards: Non-static method JLoader::register() should not be called statically in /home/zephyr/public_html/libraries/loader.php on line 138

Strict Standards: Non-static method JLoader::import() should not be called statically in /home/zephyr/public_html/libraries/loader.php on line 186

Strict Standards: Non-static method JLoader::register() should not be called statically in /home/zephyr/public_html/libraries/loader.php on line 71

Strict Standards: Non-static method JLoader::load() should not be called statically in /home/zephyr/public_html/libraries/loader.php on line 161

Strict Standards: Non-static method JLoader::register() should not be called statically in /home/zephyr/public_html/libraries/loader.php on line 138

Strict Standards: Non-static method JLoader::import() should not be called statically in /home/zephyr/public_html/libraries/loader.php on line 186

Strict Standards: Non-static method JLoader::import() should not be called statically in /home/zephyr/public_html/libraries/loader.php on line 186

Strict Standards: Non-static method JLoader::load() should not be called statically in /home/zephyr/public_html/libraries/loader.php on line 161

Strict Standards: Non-static method JLoader::register() should not be called statically in /home/zephyr/public_html/libraries/loader.php on line 138

Strict Standards: Non-static method JLoader::register() should not be called statically in /home/zephyr/public_html/plugins/system/legacy/mambothandler.php on line 19

Strict Standards: Non-static method JPluginHelper::_import() should not be called statically in /home/zephyr/public_html/libraries/joomla/plugin/helper.php on line 97

Strict Standards: Non-static method JLoader::import() should not be called statically in /home/zephyr/public_html/libraries/loader.php on line 186

Strict Standards: Non-static method JDispatcher::getInstance() should not be called statically in /home/zephyr/public_html/libraries/joomla/plugin/helper.php on line 140

Strict Standards: Non-static method JLoader::load() should not be called statically in /home/zephyr/public_html/libraries/loader.php on line 161

Strict Standards: Non-static method JLoader::register() should not be called statically in /home/zephyr/public_html/libraries/loader.php on line 138

Strict Standards: Non-static method JPluginHelper::_import() should not be called statically in /home/zephyr/public_html/libraries/joomla/plugin/helper.php on line 97

Strict Standards: Non-static method JLoader::import() should not be called statically in /home/zephyr/public_html/libraries/loader.php on line 186

Strict Standards: Non-static method JLoader::import() should not be called statically in /home/zephyr/public_html/libraries/loader.php on line 186

Strict Standards: Non-static method JDispatcher::getInstance() should not be called statically in /home/zephyr/public_html/libraries/joomla/plugin/helper.php on line 140

Strict Standards: Non-static method JPluginHelper::getPlugin() should not be called statically in /home/zephyr/public_html/libraries/joomla/plugin/helper.php on line 147

Strict Standards: Non-static method JPluginHelper::_load() should not be called statically in /home/zephyr/public_html/libraries/joomla/plugin/helper.php on line 41

Strict Standards: Non-static method JPluginHelper::_import() should not be called statically in /home/zephyr/public_html/libraries/joomla/plugin/helper.php on line 97

Strict Standards: Non-static method JLoader::import() should not be called statically in /home/zephyr/public_html/libraries/loader.php on line 186

Strict Standards: Non-static method JLoader::import() should not be called statically in /home/zephyr/public_html/libraries/loader.php on line 186

Strict Standards: Non-static method JLoader::import() should not be called statically in /home/zephyr/public_html/libraries/loader.php on line 186

Strict Standards: Non-static method JDispatcher::getInstance() should not be called statically in /home/zephyr/public_html/libraries/joomla/plugin/helper.php on line 140

Strict Standards: Non-static method JPluginHelper::getPlugin() should not be called statically in /home/zephyr/public_html/libraries/joomla/plugin/helper.php on line 147

Strict Standards: Non-static method JPluginHelper::_load() should not be called statically in /home/zephyr/public_html/libraries/joomla/plugin/helper.php on line 41

Strict Standards: Non-static method JPluginHelper::_import() should not be called statically in /home/zephyr/public_html/libraries/joomla/plugin/helper.php on line 97

Strict Standards: Non-static method JLoader::import() should not be called statically in /home/zephyr/public_html/libraries/loader.php on line 186

Strict Standards: Non-static method JLoader::import() should not be called statically in /home/zephyr/public_html/libraries/loader.php on line 186

Strict Standards: Non-static method JLoader::register() should not be called statically in /home/zephyr/public_html/libraries/loader.php on line 71

Strict Standards: Non-static method JLoader::load() should not be called statically in /home/zephyr/public_html/libraries/loader.php on line 161

Strict Standards: Non-static method JLoader::register() should not be called statically in /home/zephyr/public_html/libraries/loader.php on line 138

Strict Standards: Non-static method JDispatcher::getInstance() should not be called statically in /home/zephyr/public_html/libraries/joomla/plugin/helper.php on line 140

Strict Standards: Non-static method JPluginHelper::getPlugin() should not be called statically in /home/zephyr/public_html/libraries/joomla/plugin/helper.php on line 147

Strict Standards: Non-static method JPluginHelper::_load() should not be called statically in /home/zephyr/public_html/libraries/joomla/plugin/helper.php on line 41

Strict Standards: Non-static method JLoader::import() should not be called statically in /home/zephyr/public_html/libraries/loader.php on line 186

Strict Standards: Non-static method JLoader::import() should not be called statically in /home/zephyr/public_html/libraries/loader.php on line 186

Strict Standards: Non-static method JLoader::import() should not be called statically in /home/zephyr/public_html/libraries/loader.php on line 186

Strict Standards: Redefining already defined constructor for class sh_Net_URL in /home/zephyr/public_html/administrator/components/com_sh404sef/sh404sef.class.php on line 2412

Strict Standards: Non-static method JLoader::import() should not be called statically in /home/zephyr/public_html/libraries/loader.php on line 186

Strict Standards: Non-static method JLoader::register() should not be called statically in /home/zephyr/public_html/libraries/loader.php on line 71

Strict Standards: Non-static method JRequest::getVar() should not be called statically in /home/zephyr/public_html/administrator/components/com_sh404sef/sh404sef.class.php on line 2175

Strict Standards: Non-static method JRequest::_cleanVar() should not be called statically in /home/zephyr/public_html/libraries/joomla/environment/request.php on line 151

Strict Standards: Non-static method JFilterInput::getInstance() should not be called statically in /home/zephyr/public_html/libraries/joomla/environment/request.php on line 577

Strict Standards: Non-static method JApplicationHelper::getClientInfo() should not be called statically in /home/zephyr/public_html/administrator/components/com_sh404sef/sh404sef.class.php on line 2175

Strict Standards: Non-static method JLoader::import() should not be called statically in /home/zephyr/public_html/libraries/loader.php on line 186

Strict Standards: Non-static method JLanguage::getLanguagePath() should not be called statically in /home/zephyr/public_html/administrator/components/com_sh404sef/sh404sef.class.php on line 2179

Strict Standards: Non-static method JFolder::folders() should not be called statically in /home/zephyr/public_html/administrator/components/com_sh404sef/sh404sef.class.php on line 2180

Strict Standards: Non-static method JPath::clean() should not be called statically in /home/zephyr/public_html/libraries/joomla/filesystem/folder.php on line 475

Strict Standards: Non-static method JFolder::files() should not be called statically in /home/zephyr/public_html/administrator/components/com_sh404sef/sh404sef.class.php on line 2184

Strict Standards: Non-static method JPath::clean() should not be called statically in /home/zephyr/public_html/libraries/joomla/filesystem/folder.php on line 414

Strict Standards: Non-static method JFactory::getXMLParser() should not be called statically in /home/zephyr/public_html/administrator/components/com_sh404sef/sh404sef.class.php on line 2186

Strict Standards: Non-static method JLoader::import() should not be called statically in /home/zephyr/public_html/libraries/loader.php on line 186

Strict Standards: Non-static method JFolder::files() should not be called statically in /home/zephyr/public_html/administrator/components/com_sh404sef/sh404sef.class.php on line 2184

Strict Standards: Non-static method JPath::clean() should not be called statically in /home/zephyr/public_html/libraries/joomla/filesystem/folder.php on line 414

Strict Standards: Non-static method JFactory::getXMLParser() should not be called statically in /home/zephyr/public_html/administrator/components/com_sh404sef/sh404sef.class.php on line 2186

Strict Standards: Non-static method JLoader::import() should not be called statically in /home/zephyr/public_html/libraries/loader.php on line 186

Strict Standards: Non-static method JFolder::files() should not be called statically in /home/zephyr/public_html/administrator/components/com_sh404sef/sh404sef.class.php on line 2184

Strict Standards: Non-static method JPath::clean() should not be called statically in /home/zephyr/public_html/libraries/joomla/filesystem/folder.php on line 414

Strict Standards: Non-static method JFactory::getXMLParser() should not be called statically in /home/zephyr/public_html/administrator/components/com_sh404sef/sh404sef.class.php on line 2186

Strict Standards: Non-static method JLoader::import() should not be called statically in /home/zephyr/public_html/libraries/loader.php on line 186

Strict Standards: Non-static method JLoader::load() should not be called statically in /home/zephyr/public_html/libraries/loader.php on line 161

Strict Standards: Non-static method JLoader::register() should not be called statically in /home/zephyr/public_html/libraries/loader.php on line 138

Strict Standards: Non-static method JLoader::import() should not be called statically in /home/zephyr/public_html/libraries/loader.php on line 186

Strict Standards: Non-static method JLoader::import() should not be called statically in /home/zephyr/public_html/libraries/loader.php on line 186

Strict Standards: Non-static method JLoader::import() should not be called statically in /home/zephyr/public_html/libraries/loader.php on line 186

Strict Standards: Non-static method JLoader::load() should not be called statically in /home/zephyr/public_html/libraries/loader.php on line 161

Strict Standards: Non-static method JLoader::register() should not be called statically in /home/zephyr/public_html/libraries/loader.php on line 138

Strict Standards: Non-static method JLoader::import() should not be called statically in /home/zephyr/public_html/libraries/loader.php on line 186

Strict Standards: Non-static method JLoader::register() should not be called statically in /home/zephyr/public_html/libraries/loader.php on line 71

Strict Standards: Non-static method JLoader::load() should not be called statically in /home/zephyr/public_html/libraries/loader.php on line 161

Strict Standards: Non-static method JLoader::register() should not be called statically in /home/zephyr/public_html/libraries/loader.php on line 138

Strict Standards: Non-static method JLoader::register() should not be called statically in /home/zephyr/public_html/libraries/joomla/cache/cache.php on line 19

Strict Standards: Non-static method JLoader::load() should not be called statically in /home/zephyr/public_html/libraries/loader.php on line 161

Strict Standards: Non-static method JLoader::register() should not be called statically in /home/zephyr/public_html/libraries/loader.php on line 138

Strict Standards: Non-static method JLoader::load() should not be called statically in /home/zephyr/public_html/libraries/loader.php on line 161

Strict Standards: Non-static method JLoader::register() should not be called statically in /home/zephyr/public_html/libraries/loader.php on line 138

Strict Standards: Declaration of JCacheStorage::get() should be compatible with JObject::get($property, $default = NULL) in /home/zephyr/public_html/libraries/joomla/cache/storage.php on line 173

Strict Standards: Non-static method JLoader::load() should not be called statically in /home/zephyr/public_html/libraries/loader.php on line 161

Strict Standards: Non-static method JLoader::register() should not be called statically in /home/zephyr/public_html/libraries/loader.php on line 138

Strict Standards: Non-static method JRequest::getInt() should not be called statically in /home/zephyr/public_html/index.php on line 55

Strict Standards: Non-static method JRequest::getVar() should not be called statically in /home/zephyr/public_html/libraries/joomla/environment/request.php on line 179

Strict Standards: Non-static method JRequest::_cleanVar() should not be called statically in /home/zephyr/public_html/libraries/joomla/environment/request.php on line 134

Strict Standards: Non-static method JFilterInput::getInstance() should not be called statically in /home/zephyr/public_html/libraries/joomla/environment/request.php on line 577

Strict Standards: Non-static method JLoader::import() should not be called statically in /home/zephyr/public_html/libraries/loader.php on line 186

Strict Standards: Non-static method JLoader::import() should not be called statically in /home/zephyr/public_html/libraries/loader.php on line 186

Strict Standards: Non-static method JRequest::getCmd() should not be called statically in /home/zephyr/public_html/plugins/system/plg_reg_redirector.php on line 16

Strict Standards: Non-static method JRequest::getVar() should not be called statically in /home/zephyr/public_html/libraries/joomla/environment/request.php on line 255

Strict Standards: Non-static method JRequest::_cleanVar() should not be called statically in /home/zephyr/public_html/libraries/joomla/environment/request.php on line 134

Strict Standards: Non-static method JFilterInput::getInstance() should not be called statically in /home/zephyr/public_html/libraries/joomla/environment/request.php on line 577

Strict Standards: Non-static method JRequest::getCmd() should not be called statically in /home/zephyr/public_html/plugins/system/plg_reg_redirector.php on line 17

Strict Standards: Non-static method JRequest::getVar() should not be called statically in /home/zephyr/public_html/libraries/joomla/environment/request.php on line 255

Strict Standards: Non-static method JRequest::_cleanVar() should not be called statically in /home/zephyr/public_html/libraries/joomla/environment/request.php on line 151

Strict Standards: Non-static method JFilterInput::getInstance() should not be called statically in /home/zephyr/public_html/libraries/joomla/environment/request.php on line 577

Strict Standards: Non-static method JRequest::getCmd() should not be called statically in /home/zephyr/public_html/plugins/system/plg_reg_redirector.php on line 18

Strict Standards: Non-static method JRequest::getVar() should not be called statically in /home/zephyr/public_html/libraries/joomla/environment/request.php on line 255

Strict Standards: Non-static method JRequest::_cleanVar() should not be called statically in /home/zephyr/public_html/libraries/joomla/environment/request.php on line 134

Strict Standards: Non-static method JFilterInput::getInstance() should not be called statically in /home/zephyr/public_html/libraries/joomla/environment/request.php on line 577

Strict Standards: Non-static method JPluginHelper::getPlugin() should not be called statically in /home/zephyr/public_html/plugins/system/plg_reg_redirector.php on line 21

Strict Standards: Non-static method JPluginHelper::_load() should not be called statically in /home/zephyr/public_html/libraries/joomla/plugin/helper.php on line 41

Strict Standards: Non-static method JLoader::import() should not be called statically in /home/zephyr/public_html/libraries/loader.php on line 186

Strict Standards: Non-static method JRequest::getCmd() should not be called statically in /home/zephyr/public_html/index.php on line 67

Strict Standards: Non-static method JRequest::getVar() should not be called statically in /home/zephyr/public_html/libraries/joomla/environment/request.php on line 255

Strict Standards: Non-static method JRequest::_cleanVar() should not be called statically in /home/zephyr/public_html/libraries/joomla/environment/request.php on line 134

Strict Standards: Non-static method JFilterInput::getInstance() should not be called statically in /home/zephyr/public_html/libraries/joomla/environment/request.php on line 577

Strict Standards: Non-static method JLoader::import() should not be called statically in /home/zephyr/public_html/libraries/loader.php on line 186

Strict Standards: Non-static method JLoader::register() should not be called statically in /home/zephyr/public_html/libraries/loader.php on line 71

Strict Standards: Non-static method JLoader::load() should not be called statically in /home/zephyr/public_html/libraries/loader.php on line 161

Strict Standards: Non-static method JLoader::register() should not be called statically in /home/zephyr/public_html/libraries/loader.php on line 138

Strict Standards: Non-static method JLoader::register() should not be called statically in /home/zephyr/public_html/libraries/joomla/document/document.php on line 19

Strict Standards: Non-static method JLoader::load() should not be called statically in /home/zephyr/public_html/libraries/loader.php on line 161

Strict Standards: Non-static method JLoader::register() should not be called statically in /home/zephyr/public_html/libraries/loader.php on line 138

Strict Standards: Non-static method JLoader::import() should not be called statically in /home/zephyr/public_html/libraries/loader.php on line 186

Strict Standards: Non-static method JLoader::import() should not be called statically in /home/zephyr/public_html/libraries/loader.php on line 186

Strict Standards: Non-static method JLoader::import() should not be called statically in /home/zephyr/public_html/libraries/loader.php on line 186

Strict Standards: Non-static method JLoader::import() should not be called statically in /home/zephyr/public_html/libraries/loader.php on line 186

Strict Standards: Non-static method JLoader::import() should not be called statically in /home/zephyr/public_html/libraries/loader.php on line 186

Strict Standards: Non-static method JLoader::load() should not be called statically in /home/zephyr/public_html/libraries/loader.php on line 161

Strict Standards: Non-static method JLoader::register() should not be called statically in /home/zephyr/public_html/libraries/loader.php on line 138

Strict Standards: Non-static method JLoader::load() should not be called statically in /home/zephyr/public_html/libraries/loader.php on line 161

Strict Standards: Non-static method JLoader::register() should not be called statically in /home/zephyr/public_html/libraries/loader.php on line 138

Strict Standards: Declaration of JDocumentRendererRSS::render() should be compatible with JDocumentRenderer::render($name, $params = Array, $content = NULL) in /home/zephyr/public_html/libraries/joomla/document/feed/renderer/rss.php on line 31

Strict Standards: Non-static method JLoader::import() should not be called statically in /home/zephyr/public_html/libraries/loader.php on line 186

Strict Standards: Non-static method JLoader::import() should not be called statically in /home/zephyr/public_html/libraries/loader.php on line 186

Strict Standards: Non-static method JLoader::import() should not be called statically in /home/zephyr/public_html/libraries/loader.php on line 186

Strict Standards: Non-static method JLoader::import() should not be called statically in /home/zephyr/public_html/libraries/loader.php on line 186

Strict Standards: Only variables should be assigned by reference in /home/zephyr/public_html/libraries/joomla/document/feed/renderer/rss.php on line 53

Strict Standards: Non-static method JLoader::import() should not be called statically in /home/zephyr/public_html/libraries/loader.php on line 186

Strict Standards: Non-static method JLoader::import() should not be called statically in /home/zephyr/public_html/libraries/loader.php on line 186

Strict Standards: Non-static method JLoader::import() should not be called statically in /home/zephyr/public_html/libraries/loader.php on line 186

Strict Standards: Non-static method JLoader::import() should not be called statically in /home/zephyr/public_html/libraries/loader.php on line 186

Strict Standards: Non-static method JLoader::import() should not be called statically in /home/zephyr/public_html/libraries/loader.php on line 186

Strict Standards: Non-static method JLoader::import() should not be called statically in /home/zephyr/public_html/libraries/loader.php on line 186

Strict Standards: Non-static method JLoader::import() should not be called statically in /home/zephyr/public_html/libraries/loader.php on line 186

Strict Standards: Non-static method JLoader::import() should not be called statically in /home/zephyr/public_html/libraries/loader.php on line 186

Strict Standards: Non-static method JLoader::import() should not be called statically in /home/zephyr/public_html/libraries/loader.php on line 186

Strict Standards: Non-static method JLoader::load() should not be called statically in /home/zephyr/public_html/libraries/loader.php on line 161

Strict Standards: Non-static method JLoader::register() should not be called statically in /home/zephyr/public_html/libraries/loader.php on line 138

Strict Standards: Non-static method JLoader::import() should not be called statically in /home/zephyr/public_html/libraries/loader.php on line 186

Strict Standards: Non-static method JLoader::register() should not be called statically in /home/zephyr/public_html/libraries/loader.php on line 71

Strict Standards: Non-static method JLoader::load() should not be called statically in /home/zephyr/public_html/libraries/loader.php on line 161

Strict Standards: Non-static method JLoader::register() should not be called statically in /home/zephyr/public_html/libraries/loader.php on line 138

Strict Standards: Non-static method JLoader::import() should not be called statically in /home/zephyr/public_html/libraries/loader.php on line 186

Strict Standards: Non-static method JResponse::toString() should not be called statically in /home/zephyr/public_html/index.php on line 88

Strict Standards: Non-static method JResponse::getBody() should not be called statically in /home/zephyr/public_html/libraries/joomla/environment/response.php on line 190

Strict Standards: Non-static method JResponse::allowCache() should not be called statically in /home/zephyr/public_html/libraries/joomla/environment/response.php on line 197

Strict Standards: Non-static method JResponse::setHeader() should not be called statically in /home/zephyr/public_html/libraries/joomla/environment/response.php on line 199

Strict Standards: Non-static method JResponse::setHeader() should not be called statically in /home/zephyr/public_html/libraries/joomla/environment/response.php on line 200

Strict Standards: Non-static method JResponse::setHeader() should not be called statically in /home/zephyr/public_html/libraries/joomla/environment/response.php on line 201

Strict Standards: Non-static method JResponse::setHeader() should not be called statically in /home/zephyr/public_html/libraries/joomla/environment/response.php on line 202

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Strict Standards: Non-static method JResponse::sendHeaders() should not be called statically in /home/zephyr/public_html/libraries/joomla/environment/response.php on line 206
Zephyr Foundation The Zephyr Foundation is dedicated to expanding clinical research studies focused on a group of HIV+ individuals known as "HIV Controllers". http://zephyrfoundation.org/index.php?option=com_content&view=frontpage Mon, 24 Apr 2017 11:13:45 +0000 Joomla! 1.5 - Open Source Content Management en-us New site coming soon! http://zephyrfoundation.org/index.php?option=com_content&view=article&id=81:newsite&catid=1:zephyr&Itemid=8 http://zephyrfoundation.org/index.php?option=com_content&view=article&id=81:newsite&catid=1:zephyr&Itemid=8 jeff@koertzen.com (Jeff Koertzen) frontpage Fri, 12 Jul 2013 04:43:07 +0000 Zephyr Foundation http://zephyrfoundation.org/index.php?option=com_content&view=article&id=1:zephyr&catid=14:zephyr&Itemid=16 http://zephyrfoundation.org/index.php?option=com_content&view=article&id=1:zephyr&catid=14:zephyr&Itemid=16 The Organization for Long-Term Non-Progressors (LTNPs) of HIV 

As researchers around the world strive toward a therapeutic vaccine with which to curb the AIDS pandemic, they begin to focus on a small but growing band of people who test positive for the Human Immuno-Deficiency Virus (HIV). Their views, and their clinical studies, reveal that these rare individuals may hold a possible key to unlock the mystery of AIDS. This growing band of individuals is called 'Long-Term Non-Progressors' (LTNPs) and HIV Controllers (HCs). As of June 2010, 1725 of these individuals have been identified and volunteer to participate in clinical research studies throughout the world.

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lwillenberg@zephyrfoundation.org (Loreen Willenberg) frontpage Fri, 25 Apr 2008 20:59:41 +0000
From Mice Into Men http://zephyrfoundation.org/index.php?option=com_content&view=article&id=62:from-mice-into-men-from-poz-oct-nov-2010&catid=17:hiv&Itemid=8 http://zephyrfoundation.org/index.php?option=com_content&view=article&id=62:from-mice-into-men-from-poz-oct-nov-2010&catid=17:hiv&Itemid=8

POZ Magazine
October / November 2010

by Regan Hofmann with Tim Horn

The gap between groundbreaking scientific discoveries and a game-changing cure has never been greater. And yet, researchers say we could be closer to a cure than many have dared believe. To close that gap, and increase the chances we’ll see the end of AIDS in our lifetimes, we need more advocacy, a lot more money and the courage to get as many viable options out of mice and into humans. You in?

  
 
Click here to read a digital edition of this article.

Cure. It’s a word few have been willing to pair with AIDS since we thought we had the virus kicked in ’96. For nearly 15 years, talk of a cure has been verboten. Those who have dared utter it (including on the pages of this magazine) were dismissed as dreamers. Since the late 1990s, research, advocacy and funding around HIV/AIDS have focused almost exclusively on prevention and treatment. And yet, it has become clear that we can neither treat nor prevent our way out of the pandemic. The ethical, logistical, sociological and financial barriers to trying to end AIDS with pills and awareness campaigns are proving too great.

]]> webmaster@zephyrfoundation.org (webmaster) frontpage Wed, 06 Oct 2010 03:05:47 +0000 Study Finds Some Elite Controllers Indistinguishable From HIV-negative Persons http://zephyrfoundation.org/index.php?option=com_content&view=article&id=76:study-finds-some-elite-controllers-indistinguishable-from-hiv-negative-persons&catid=1:zephyr&Itemid=8 http://zephyrfoundation.org/index.php?option=com_content&view=article&id=76:study-finds-some-elite-controllers-indistinguishable-from-hiv-negative-persons&catid=1:zephyr&Itemid=8 In an abstract published online ahead of print today in the Journal of Virology, International HIV Controller Study collaborators characterized genetic signatures in the CD4 T-cells of an "unselected" cohort of elite controllers to further elucidate underlying immunological and virological mechanisms of HIV-1 control. Genetic profiles of the majority of elite controllers were similiar to patients on antiretroviral therapy, although different from HIV-1 negative persons. However, in a smaller proportion of elite controllers, an alternative genetic pattern was observed that was indistinguishable from that of HIV-1 negative persons, and different from individuals on highly active antiretroviral medications. Significantly higher CD4 T-cell counts and smaller levels of HIV-1 specific CD8+ T-cell responses were measured in this sub-group of elite controllers. who did not significantly differ from other elite controllers in respect to viral loads and HLA class I alleles. This study team concludes that the data identify a "specific subgroup of elite controllers whose immunological and gene expression characteristics approximate those of HIV-1 negative persons."
Abstract Accessed 12/22/10, at: http://jvi.asm.org/cgi/content/abstract/JVI.01846-10v1
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lwillenberg@zephyrfoundation.org (Loreen Willenberg) frontpage Wed, 22 Dec 2010 20:46:25 +0000
The 2010 scientific strategic plan of the Global HIV Vaccine Enterprise http://zephyrfoundation.org/index.php?option=com_content&view=article&id=56:the-2010-scientific-strategic-plan-of-the-global-hiv-vaccine-enterprise&catid=17:hiv&Itemid=8 http://zephyrfoundation.org/index.php?option=com_content&view=article&id=56:the-2010-scientific-strategic-plan-of-the-global-hiv-vaccine-enterprise&catid=17:hiv&Itemid=8 Commentary from Nature Medicine
Full article is freely available at
Nature Medicine
 
The Council of the Global HIV Vaccine Enterprise, Seth Berkley, Kenneth Bertram, Jean-François Delfraissy, Ruxandra Draghia-Akli, Anthony Fauci, Cynthia Hallenbeck, Madame Jeannette Kagame, Peter Kim, Daisy Mafubelu, Malegapuru W Makgoba, Peter Piot, Mark Walport, Mitchell Warren & Tadataka Yamada for Members of the Enterprise, José Esparza, Catherine Hankins, Margaret I Johnston, Yves Lévy & Manuel Romaris for Alternate members, Rafi Ahmed & Alan Bernstein for Ex-officio members
AffiliationsCorresponding author
Nature Medicine 16 , 981–989 (2010) doi:10.1038/nm0910-981 
 
An important moment in HIV vaccine research
HIV/AIDS remains one of humanity's greatest challenges. Since 1981, it has claimed over 25 million lives and is
currently responsible for over 2.5 million new infections worldwide each year1. Although progress has been made in
preventing new HIV infections and in lowering the annual number of AIDS-related deaths through comprehensive
prevention programs and increased access to antiretroviral therapy, the number of people living with HIV—now over 33
million—continues to grow1. Currently, only two out of five people who need treatment receive it, and even this modest
level of progress in treatment is in jeopardy, as the availability of donor funds plateaus or declines2. Whereas universal
access to treatment is an ambitious goal, the annual accrual of newly infected individuals who require treatment
testifies to the urgent need for more effective prevention strategies. Vaccines are the primary public health intervention
for dozens of infectious diseases worldwide; they are easy to administer and yield lasting effects. As one of the most
powerful tools for preventing infection against other infectious diseases, a safe, effective, accessible HIV vaccine is
therefore one of our greatest priorities—and one of science's greatest challenges.
The unique ability of HIV to evade and suppress the immune response, its extraordinary genetic diversity, the
properties of its envelope glycoprotein and the ability to establish systemic infection within days and to induce
dysfunction and death of the immune cells needed to mount a protective response have posed unprecedented
challenges for vaccine development3. Nonetheless, although a highly effective HIV vaccine remains elusive, we have
never been closer to the target. Among the most visible achievements of the past five years were the results of RV144,
the trial conducted in Thailand, that showed that a poxvirus-protein prime-boost combination provided modest (31%)
protection against HIV acquisition4. These results represent the first-ever demonstration of any level of efficacy in
preventing HIV acquisition in humans by a vaccine. Although many questions remain, the results of the RV144 trial
have brought renewed energy to the field and created a new lens through which to evaluate future priorities and set
strategic directions.
There have been other key advances in HIV vaccine research over the past five years. They include a growing
understanding of the role of the mucosa as a barrier to sexually transmitted HIV infection5, descriptions of the earliest
immunological responses in humans after acute HIV infection6, the demonstration that HIV infection in humans is
usually initiated by one or a very small number of founder viruses7, 8, the development of computational algorithms to
inform the design of unique mosaic immunogens to address the challenge of viral sequence diversity by achieving
maximum epitope coverage while preserving natural antigen expression and processing9, new insights into the
immunological and genetic basis for the ability of some people to control the virus or prevent virus acquisition (socalled
'elite controllers' and 'exposed but uninfected persons', respectively)10, 11, the first proof of substantive simian
immunodeficiency virus control by CD8+ effector memory T cells induced through vaccination12, the isolation of new
antibodies with broadly neutralizing activity from HIV-infected subjects13, 14, 15 and appreciation of the possible role of
non-neutralizing antibodies in protection16, 17, 18.
Progress in other areas of biomedicine, including the development of faster and cheaper DNA sequencing, highthroughput
and computational technologies, will increasingly affect the progress of HIV vaccine research and
development. Last, although two large-scale human efficacy trials—STEP and Phambili—failed to confer protection19,
further analysis of these trials has influenced current thinking about the direction of HIV vaccine design, development
and clinical evaluation20, 21.
It is now incumbent upon the field to translate the opportunities created by these developments into a safe and
effective HIV vaccine suitable for use in populations with markedly different epidemiological, social, genetic and
behavioral characteristics. This next stage in HIV vaccine research requires a strengthened global strategy that
incorporates current efforts and encourages new and existing partners from high-, low- and middle-income countries to
embark on a shared scientific agenda.
...
Full article freely available at Nature Medicine
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webmaster@zephyrfoundation.org (webmaster) frontpage Tue, 07 Sep 2010 23:53:42 +0000
Elite control of HIV infection: implications for vaccine design (Summary) http://zephyrfoundation.org/index.php?option=com_content&view=article&id=34:elite-control-of-hiv-infection-implications-for-vaccine-design-summary&catid=21:research&Itemid=8 http://zephyrfoundation.org/index.php?option=com_content&view=article&id=34:elite-control-of-hiv-infection-implications-for-vaccine-design-summary&catid=21:research&Itemid=8 Background: ‘Elite controllers’ are rare HIV-infected individuals who are able to spontaneously control HIV replication without medication, maintaining viral loads that are consistently below the limits of detection by currently available commercial assays.

Objective: To examine studies of elite controllers that may elucidate mechanisms of HIV immune control useful in designing a vaccine.

Methods: Recent literature on HIV controllers and studies that have evaluated aspects of viral and host immunology that correlate with viral control are examined.

Results/conclusions: Although many elements of innate and adaptive immunity are associated with control of HIV infection, the specific mechanism(s) by which elite controllers achieve control remain undefined. Ongoing studies of elite controllers, including those examining host genetic polymorphisms, should facilitate the definition of an effective HIV-specific immune response and guide vaccine design.

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webmaster@zephyrfoundation.org (BM Baker‌, BL Block‌, AC Rothchild‌ & BD Walker‌) frontpage Sun, 19 Jul 2009 06:44:50 +0000
Potential Mechanism of Long Term Control of HIV http://zephyrfoundation.org/index.php?option=com_content&view=article&id=32:potential-mechanism-of-long-term-control-of-hiv&catid=21:research&Itemid=8 http://zephyrfoundation.org/index.php?option=com_content&view=article&id=32:potential-mechanism-of-long-term-control-of-hiv&catid=21:research&Itemid=8 Australian researchers have evaluated several potential mechanisms that may contribute to conferring long term non-progression in HIV infection. The reasons why some individuals can control HIV progression better than others remain under investigation. Wayne B. Dyer and colleagues in Sydney, Australia, evaluated the blood from a group of study patients with transfusion-acquired HIV infection. Within this group, 13 patients were identified as LTNPs. Over the next 12 years, 5 of the study group members retained their LTNP status even after 23 to 26 years infection, but only 3 retained a status of elite LTNP. The researchers examined multiple potential mechanisms that could have differentiated the delayed progressors from elite LTNPs in this study group.

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ereay@ucdavis.edu (Elizabeth Reay) frontpage Sun, 21 Jun 2009 04:54:22 +0000
Handful of 20-year HIV survivors hold key to discovering vaccine http://zephyrfoundation.org/index.php?option=com_content&view=article&id=23:independent-nature-3-16&catid=21:research&Itemid=8 http://zephyrfoundation.org/index.php?option=com_content&view=article&id=23:independent-nature-3-16&catid=21:research&Itemid=8 Researchers are looking into the antibodies that provide natural immunity

Kai Brothers contracted HIV in the 80s, but never developed AIDS.In a desperate attempt to reverse 25 years of failure to develop an AIDS vaccine, scientists have a new approach: studying people who have been infected with HIV for many years without any signs of ill-health. The patients' secret? Natural immunity.

The researchers have investigated the virus-fighting antibodies found in the blood of six long-term survivors of HIV whose own immune systems appear to be capable of shrugging off the virus. Results of tests show that a prototype vaccine made from several of the antibodies produced by those long-term survivors can prevent HIV from infecting human cells. The experiments have been successful on human cells growing in a test tube. Now further trials are planned on laboratory animals and human volunteers.

The search for an AIDS vaccine has suffered a series of setbacks over the years. The most recent was the failure of the most promising potential vaccine, in a major clinical trial by the US drug company Merck. The trial, which had involved thousands of volunteers, had to be abandoned at the end of 2007 because of fears that the trial vaccine might in fact make patients more susceptible to AIDS.

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webmaster@zephyrfoundation.org (Steve Connor, Independent Science Editor) frontpage Mon, 16 Mar 2009 08:00:00 +0000
Antibodies Present in Long-Term HIV Survivors Could Contribute to Vaccine Development, Study Says http://zephyrfoundation.org/index.php?option=com_content&view=article&id=22:kaiser-nature-3-16&catid=21:research&Itemid=8 http://zephyrfoundation.org/index.php?option=com_content&view=article&id=22:kaiser-nature-3-16&catid=21:research&Itemid=8 HIV-positive people who do not develop AIDS and do not require antiretroviral medication could provide insight for new strategies in vaccine development, according to a study published Sunday in the journal Nature, London's Independent reports. Michel Nussenzweig — head of Rockefeller University's Laboratory of Molecular Immunology and author of the study — said his research aimed to harness natural mechanisms to target HIV rather than use synthetically produced antibodies, some of which have failed in earlier HIV vaccine trials.
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webmaster@zephyrfoundation.org (Kaiser Network) frontpage Mon, 16 Mar 2009 08:00:00 +0000